Application of 23 Novel Serological Markers for Identifying Recent Exposure to Plasmodium vivax Parasites in an Endemic Population of Western Thailand

S Chotirat; N Nekkab; C Kumpitak; J Hietanen; MT White; K Kiattibutr; P Sa-angchai; J Brewster; K Schoffer; E Takashima; T Tsuboi; M Harbers; CE Chitnis; J Healer; WH Tham; W Nguitragool; I Mueller; J Sattabongkot; RJ Longley

Journal article

Application of 23 Novel Serological Markers for Identifying Recent Exposure to Plasmodium vivax Parasites in an Endemic Population of Western Thailand

S Chotirat, N Nekkab, C Kumpitak, J Hietanen, MT White, K Kiattibutr, P Sa-angchai, J Brewster, K Schoffer, E Takashima, T Tsuboi, M Harbers, CE Chitnis, J Healer, WH Tham, W Nguitragool, I Mueller, J Sattabongkot, RJ Longley

Frontiers in Microbiology | FRONTIERS MEDIA SA | Published : 2021

DOI: 10.3389/fmicb.2021.643501

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Abstract

Thailand is aiming for malaria elimination by the year 2030. However, the high proportion of asymptomatic infections and the presence of the hidden hypnozoite stage of Plasmodium vivax are impeding these efforts. We hypothesized that a validated surveillance tool utilizing serological markers of recent exposure to P. vivax infection could help to identify areas of ongoing transmission. The objective of this exploratory study was to assess the ability of P. vivax serological exposure markers to detect residual transmission “hot-spots” in Western Thailand. Total IgG levels were measured against a panel of 23 candidate P. vivax serological exposure markers using a multiplexed bead-based assay. ..

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University of Melbourne Researchers

Wai-Hong Tham Author

Ivo Mueller Author

Rhea Longley Author

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Awarded by Case Western Reserve University

Funding Acknowledgements

Funding for this study was provided by the National Institute of Allergy and Infectious Diseases (NIH grant 5R01 AI 104822 to JS), the National Health and Medical Research Council (#1092789, #1134989, and #1043345 to IM, #1143187 to W-HT, and #1173210 to RL) and Global Health Innovative Technology Fund (https://www.ghitfund.org/) (T2015-142 to IM). We also acknowledged support from the National Research Council of Thailand and the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. RL was supported in part by the Jared Purton Award from the Australian and New Zealand Society of Immunology. W-HT was a Howard Hughes Medical Institute-Wellcome Trust International Research Scholar (https://www.hhmi.org/programs/biomedical-research/international-programs,similar to 208693/Z/17/Z).